Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers

The concentration of cerebrospinal fluid total protein (CSF-TP) is important for the diagnosis neurological emergencies. Recently, some Western studies have shown that current upper reference limit CSF-TP quite low older patients. However, little reported about in Asian population. In this study, we retrospectively analyzed concentrations healthy Japanese volunteers. CSF samples 69 volunteers (age range: 55–73 years) were collected by lumbar puncture, and data analyzed. mean (standard deviation) was 41.7 (12.3) mg/dL. group (≥65 years old) had higher than younger (55–64 old). 2.5th percentile 97.5th estimated as 22.5 73.2 mg/dL, respectively, which range Japan (10–40 mg/dL). Conclusions: interval population should be reconsidered precise